Week two on retatrutide brought some interesting changes. The honeymoon period of zero appetite started showing cracks, and I'm dealing with some unexpected side effects. Quick update on what's actually happening in week two. *Note: I forgot to take progress photos this week, but I'll include side-by-side comparisons from start to current state in next week's post.* ## The Hunger Comeback I felt amazing through Wednesday, then noticed some hunger noise creeping back around 3:30pm. By the time I was ready for my eating window, I was getting mildly "hangry" not yelling at anyone, just slightly annoyed when family members were in the kitchen when I needed to cook. **What this means:** The 2mg dose is still working just as well as week one. I still filled up very quickly, like I'd eaten at an all-you-can-eat buffet and overdone it. I always finished all my planned food, but it was a struggle by the end. The appetite suppression is definitely still there I just noticed the timing more this week. ## Same Simple Meals, Every Day I stuck with the same basic routine that's been working: **Daily meals:** - 2 quarter-pound ground chuck patties with Kraft American cheese slices - **Ole Xtreme Wellness ZERO Net Carbs High Fiber Tortilla Wraps** - [Buy on Amazon here](https://amzn.to/4opXTVR) - 4 XL pasture-raised eggs - [Order on Amazon here](https://amzn.to/470TxxS) Some small variations on different days, but still very carnivore and keto-focused. I can feel that I'm in moderate ketosis during the day based on past experience with this diet, my ears get hot to the touch and turn red at peak ketosis. ::gallery[{"images":["https://retatrutidelog.com/uploads/9fddba14-49f3-4819-847f-6a860041574a.jpg","https://retatrutidelog.com/uploads/de9ea9af-669e-4b71-82c5-848aeac6ba4f.jpg","https://retatrutidelog.com/uploads/cf17242b-2cf1-44a7-b119-01cb78d9d34b.jpg","https://retatrutidelog.com/uploads/58575040-b89f-411e-9eea-8ef758144353.jpg","https://retatrutidelog.com/uploads/4f42567c-836c-49df-a2ea-05a04ba50bf4.jpg"],"captions":["","","","",""]}] Still fasting until 4:30-5:00pm daily. ## Sleep and Energy Issues **The energy problem:** I'm having trouble falling asleep because I feel like I have a ton of energy at the end of the day. Never experienced this on previous diets. **My solution:** Supplementing with 5mg melatonin gummies, which helps me get drowsy enough to actually sleep. **Complicating factor:** I'm still dealing with some insomnia related to GABA deficiency from stopping alcohol use just a few weeks before starting the retatrutide cycle. Hard to tell what's causing what. ## New Side Effects This Week **Frequent urination:** I'm waking up at least twice during the night to pee, which is very unusual for me. Never been a multiple-bathroom-trips-per-night person. **Digestive changes:** Bowel movements are off schedule I'm usually very regular with timing. Also, they're much looser when they do happen. Don't feel bloated at all, just... different. ## Tracking Made Easy I'm really leaning on my private Android app that uses food images and AI to calculate mostly good-enough calorie counts. Instead of scanning barcodes and measuring everything precisely, I just snap photos of my meals and get estimates that are close enough for tracking trends. ![Screenshot_20250726-194935-fotor-20250726195049.png](https://retatrutidelog.com/uploads/4e4e9cd2-9b65-4e05-a822-525db6694473.png) This approach works perfectly for my simple, repetitive meals. The AI handles the math while I focus on consistency. ## Missing Data This Week Still no glucose or ketone blood testing strips. They're definitely ordered this time and should arrive next week, so I'll start adding a daily data table to future posts. ## Week 2 Weight Update **Starting week 2:** 322.4 lbs **End of week 2:** 318.2 lbs (weighed a day early) **Week 2 loss:** 4.2 lbs **Total loss:** 18.4 lbs in two weeks Much more reasonable numbers this week compared to the dramatic water weight drop of week one. This feels like actual fat loss rather than just water. **What's working:** - Still effective appetite control, just not as intense - Maintaining ketosis alongside retatrutide - Simple meal routine is sustainable - No major side effects **What's challenging:** - Sleep issues from excess energy - Bathroom trips disrupting sleep - Digestive timing changes - Hunger returning earlier in the day **Overall:** Still very positive about the progress, just adjusting to how the effects change over time. The initial "magic" of week one was probably unrealistic to maintain, but this still feels very manageable. **Next week:** Full progress photos, data tracking, and deciding on dosage adjustments. ::subscribe[{"variant":"default"}] --- **Disclaimer:** The information provided on this site is for **educational and informational purposes only** and reflects my **personal experiences and opinions**. It is **not** intended as medical advice, diagnosis, or treatment. Retatrutide is an **investigational drug** that is **not approved by the U.S. Food and Drug Administration (FDA)** for any use outside of clinical trials. Do not attempt to obtain or use this compound without proper legal authorization. Always consult a licensed healthcare professional before making any decisions regarding medications, supplements, or medical treatments. The author does **not** sell or distribute any pharmaceutical products. As an Amazon Associate I earn from qualifying purchases. Some links on this site may be affiliate links.